Plaquemine is a city in and the parish seat of Iberville Parish, Louisiana, United States. The population was 7,064 at the 2000 census. It is part of the Baton Rouge Metropolitan Statistical Area.

Early inhabitants of the area were Chitimacha Indians. Pierre Le Moyne d'Iberville claimed all of Louisiana in 1699 for King Louis XIV of France. Plaquemine was settled by 1775 and named for the Indian word Plakemine, which means persimmons.

Due to its location at the juncture of the Bayou Plaquemine and the Mississippi River, the village soon began to prosper and grow, beginning a long history of prosperity that has never ceased. By 1838, the town was incorporated, electing Zenon LaBauve, for whom the Garden District's main street is named, as its first mayor. Plaquemine continued to grow in the antebellum era. Massive plantations were constructed in nearby regions, including St. Louis, Nottoway and Belle Grove. The town has been the seat of Iberville Parish government since its incorporation. The former Parish Courthouse (c.1906) on Railroad Avenue has been serving as City Hall since 1985.

Plaquemine has been a Louisiana-designated Main Street City since 1993.

en.wikipedia.org/wiki/Plaquemine,_Louisiana